ISSN: 2153-0637
Songshan Shi
China
Research Article
Structural Features and Anti-Complement Activity of an Acidic Polysaccharide from Forsythia suspensa
Author(s): Shunchun Wang, Songshan Shi, Hui Lian, Chao Zhu, Huijun Wang, Ruimin Liu and SW Annie BlighShunchun Wang, Songshan Shi, Hui Lian, Chao Zhu, Huijun Wang, Ruimin Liu and SW Annie Bligh
Background: The complement system is an important host defence mechanism against the invasion of foreign materials. However, excessive or uncontrolled activation of the complement system might lead to severe complement-mediated disorders which are harmful to human bodies. There are still no desirable therapeutic compounds available on the market for complement inhibition. In recent years, researches have been focused on natural polysaccharides to modulate of the immune system because of their immunomodulatory activities and safety. In this study, Fs-8-ba2, a homogeneous acidic polysaccharide (MW ca. 7.2 kDa) was isolated from Forsythia suspensa and its anti-complementary effect was investigated.
Method: The major primary structural features of Fs-8-ba2 were elucidated using HPGPC, IR, absolute configuration, component analysis and methylatio.. Read More»
DOI:
10.4172/2153-0637.1000138