Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Soheila Porkhodadad
West Indies
Research Article
Positive Effect of Nitric Oxide on Morphine-Induced Place Conditioning in
Wistar Rats Treated by Colchicine Intra-Hippocampal CA1
Author(s): Soheila Porkhodadad, Manizheh Karami and Mohammad Reza Jalali NadoushanSoheila Porkhodadad, Manizheh Karami and Mohammad Reza Jalali Nadoushan
Colchicine is a potent alkaloid neurotoxin known as a selective neurotoxin of granular cells of hippocampal formation. This research aimed to assess the consequences of hippocampal reward circuitry damaged by colchicine. Male Wistar rats were examined for saline conditioning a week after receiving of colchicine (1-8μg/rat, intra-CA1). Control group was simply microinjected saline (1μl/rat, intra-CA1). In addition, two categories of animals pre-treated by colchicine (2,8μg/rat, intra-CA1) were evaluated for place preference induced of morphine (2.5-7.5 mg/kg, s.c.) using a three-day schedule of unbiased paradigm. Also sham operated legend “normal” group passed the conditioning by morphine. This group was pre-treated saline (1μl/rat, intra-CA1) instead of colchicine. According to the results, the injection of colchicine (1-.. View More»
DOI:
10.4172/2161-0495.1000102