Pancreatic Disorders & Therapy
Open Access
ISSN: 2165-7092
+44 1478 350008
ISSN: 2165-7092
+44 1478 350008
Shin Takasawa
840 Shijo-cho, Kashihara 634-8521, Nara
Japan
Review Article
Intermittent Hypoxia in Pancreatic beta Cells
Author(s): Hiroyo Ota, Shin Takasawa, Motoo Yamauchi, Masanori Yoshikawa, Koichi Tomoda and Hiroshi KimuraHiroyo Ota, Shin Takasawa, Motoo Yamauchi, Masanori Yoshikawa, Koichi Tomoda and Hiroshi Kimura
Sleep apnea syndrome (SAS) a highly prevalent disorder, and characterized by repetitive episodes of intermittent hypoxia (IH), i.e. recurrent episodes of oxygen desaturation during sleep, the development of daytime sleepiness, and deterioration in the quality of life. Multiple epidemiological studies have provided evidence implicating the presence of SAS as a risk factor for insulin resistance and type 2 diabetes and have reported that type 2 diabetes is associated with SAS independently of age, sex, and body habitus. One of the postulated mechanisms for the metabolic alterations associated with SAS is that IH leads to substantial alterations in both pancreatic β cell function and organ glucose homeostasis. On the other hand, hyperglycemia is known to increase the rate of β cell replication, which can provide an increased source of insulin to combat insulin resistance. Altho.. View More»
DOI:
10.4172/2165-7092.S5-004