Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Sherif Sayed
Anaesthesiology and Intensive Care
Egypt
Research Article
Effect of Morphine and Fentanyl on Inflammatory Biomarkers in Rheumatic Heart Patients Undergoing Valve Replacement Surgery
Author(s): Sherif Sayed, Hatem Maghraby, Seham Momen, Laila Hassan, Fatma Asker, Doaa Sayed and Ebtsam ElgezawiSherif Sayed, Hatem Maghraby, Seham Momen, Laila Hassan, Fatma Asker, Doaa Sayed and Ebtsam Elgezawi
Background: Cardiopulmonary bypass (CPB) is well known to be associated with a complex physiological response that is clinically manifested as a systemic inflammatory response syndrome. The aim of the study is to compare between the effect of morphine and fentanyl as part of a balanced anesthetic technique on the inflammatory reaction that occurs in cardiac valve replacement surgeries after CPB.
Material and methods: Thirty patients undergoing cardiac surgery with cardiopulmonary bypass were randomized to receive either morphine or fentanyl as part of a standardized opioid-isoflurane anesthetic; Group 1 (15 patients received morphine, IV. Group 2 (15 patients received fentanyl. Hemodynamic data were recorded. Serum concentrations of interleukin [(IL)-6 and IL-10] and [(CD 11b, CD 11c, and CD 18] were measured.
Results: .. View More»
DOI:
10.4172/2155-6148.1000412