Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Shanthi Mendis
World Health Organization,
Geneva
Sri Lanka
Research Article
Randomized Controlled Trial of Treatment of Chronic Kidney Disease of
Uncertain Aetiolgy with Enalapril
Author(s): Mathu Selvarajah, Shanthi Mendis, Saroj Jayasinghe, Rezvi Sheriff, Tilak Abeysekera and Firdosi MehtaMathu Selvarajah, Shanthi Mendis, Saroj Jayasinghe, Rezvi Sheriff, Tilak Abeysekera and Firdosi Mehta
Introduction: A double blind placebo controlled randomized trial was conducted to investigate the effect of angiotensin-converting-enzyme (ACE) inhibitor enalapril on the progression of Chronic Kidney Disease (CKD) caused by chronic exposure to nephrotoxins. Methods: 263 people aged 18-70 years diagnosed with CKD stages I, II or III who were not taking ACE inhibitors, who had no other chronic disease or contraindication for treatment with ACE inhibitors, were randomly assigned to enalapril or placebo. The main outcomes were albumin to creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). Results: The mean systolic and diastolic blood pressure levels declined significantly in both enalapril and placebo groups with no significant difference in the two groups. There was a significant improvement in the albumin to creatinine ratio in the enalapril group compared to the p.. View More»
DOI:
10.4172/2161-0495.1000281