ISSN: 2161-0495
Shanmugavelu Sithambaram
Malaysia
Research Article
Blood Profiles and Histopathological Changes of Liver and Kidney Tissues from Male Sprague Dawley Rats Treated with Ethanol Extracts of Clinacanthus nutans Leaf.
Author(s): Sajjarattul Nurul Nadia Asyura, Hazilawati Hamzah, Rosly Mohamad Shaari, Shanmugavelu Sithambaram and Noordin Mohamed MustaphaSajjarattul Nurul Nadia Asyura, Hazilawati Hamzah, Rosly Mohamad Shaari, Shanmugavelu Sithambaram and Noordin Mohamed Mustapha
Background: Clinacanthus nutans (C. nutans) or commonly known as ‘Sabah snake grass’ or ‘Belalai Gajah’ is a widely known herb used to treat Herpes simplex virus (HPV), skin rashes and snake bite.
Objective: This study aim is to evaluate the toxicity of ethanol extract of C. nutans leaf extract on 90-day sub chronic toxicity study in male Sprague Dawley rats.
Method: A total of 40, 6-week male Sprague Dawley rats were divided into 5 groups (n=8) namely control, vehicle (10% DMSO), and 3 treatment groups which received a daily oral dose of C. nutans leaf extract at 75 (low dose), 125 (medium dose), and 250 (high dose) mg/kg for 90 days via oral gavage. Blood sample were collected at the end of the experiment for evaluation of haematology and serum biochemis.. View More»
DOI:
10.4172/2161-0495.1000329