Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Shahin Shadnia
Iran, Islamic Republic of
Research Article
Is there a Correlation between Electrocardiographic Changes and Sodium Valproate Toxicity? An Investigation of 196 Cases
Author(s): Abbas Aghabiklooei, Sepide Rakhshan and Shahin ShadniaAbbas Aghabiklooei, Sepide Rakhshan and Shahin Shadnia
Introduction: Intoxication with Sodium valproate (SVP) is a growing concern owing to its increased use and availability. SVP intoxication may result in cerebral, cardiovascular, respiratory, gastrointestinal, and hematological complications. However, SVP use does not seem to be associated with significant cardiovascular effects and electrocardiographic (ECG) abnormalities. Thus, we aimed to describe SVP intoxication in a series of patients by focusing on ECG findings.
Method: Between February 2011 and February 2012, we enrolled all consecutive patients who referred to Loghman-Hakim Poison Hospital complaining of poisoning and subsequently diagnosed with SVP intoxication. For each patient, we recorded age, sex, and history of SVP use, including indication for use, number of pills ingested, time of ingestion, and total daily dose. We also inqu.. View More»
DOI:
10.4172/2161-0495.1000234