Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Sarika Gupta
Southern Sydney Haematology, Suite 7, 1-5 Derby Street, Kogarah, NSW 2217
Australia
Research Article
Combined Short Course Low Molecular Weight Heparin and Calf Compression Therapy in Prevention of Deep Vein Thrombosis after Total Knee Replacement: A Randomized Prospective Study
Author(s): Raj Ramakrishna, Sarika Gupta, Kiran Sarathy, Marijka Batterham and George KirshRaj Ramakrishna, Sarika Gupta, Kiran Sarathy, Marijka Batterham and George Kirsh
Background and aims: Anti-coagulation is an important component of post-operative Venous-Thombo-Embolic (VTE) prophylaxis but can be associated with significant complications including hemorrhage. Current guidelines favour anti-coagulation for ≥ 14 days with little evidence evaluating the efficacy of anticoagulation <14 days. Our study hypothesizes that short course Low-Molecular-Weight-Heparin (LMWH for 5-7 days) in combination with Calf Compression Device (CCD) is equally effective as standard therapy LMWH (14 days) in preventing VTE and related events amongst patients undergoing Total-Knee-Replacement (TKR).
Methods: Eighty-three patients undergoing TKR were randomly allocated to either: Group 1 short course LMWH (5-7 days) with CCD or Group 2 standard course LMWH only (14 days). Patients were followed up daily for five days post-o.. View More»
DOI:
10.4172/2329-8790.1000118