Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Samira Bouchama
Algeria
Research Article
Efficacy of L-Asparaginase Combination Therapy in Localized Extranodal NK/T-Cell Lymphoma: A Single Institution Experience
Author(s): Mohamed Amine Bekadja, Samira Bouchama, Leila Charef, Nabil Yafour, Badra Entasoltan, Abdessamed Arabi, Rachid Bouhass and Mohamed BrahimiMohamed Amine Bekadja, Samira Bouchama, Leila Charef, Nabil Yafour, Badra Entasoltan, Abdessamed Arabi, Rachid Bouhass and Mohamed Brahimi
Background: Nasal extranodal natural killer (NK)/T-cell lymphoma are highly aggressive diseases with a poor outcome. Several studies have shown the interest of L-asparaginase in salvage therapy and first-line L-asparaginase combination therapy for advanced stage extranodal NK/T-cell lymphoma should be tested in prospective trials. We report the first experience of treatment with L-asparaginase in salvage therapy and front-line based- regimen in localized nasal NK/T-cell lymphoma.
Patients and methods: We reviewed 13 consecutive localized stages I/II nasal NK/T cell lymphomas, treated in our institution over a 6 years period. 8 patients were treated with CHOP (cyclophosphamide, doxorubicin, oncovin and prednisone) regimen in first-line chemotherapy and with L-asparaginase-based regimen in salvage therapy. Five patients were treated with first-l.. View More»
DOI:
10.4172/2329-8790.1000109