Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Research Article
Cyclosporine Toxicity and Toxicokinetics Profiles in Renal Transplant
Recipients
Author(s): Ahmed Refat Ragab, Maha Khald Al-Mazroua and Sahar Abd-Elziz Al-DakroryAhmed Refat Ragab, Maha Khald Al-Mazroua and Sahar Abd-Elziz Al-Dakrory
Background: Cyclosporine is the backbone of immunosuppression in kidney transplantation. However, it leads to multiple toxic effects, most of which are dose-dependent. In this respect, the quality of renal functions is undoubtedly linked to cyclosporine drug levels.
Objective: To evaluate the association among cyclosporine trough-peak levels, dosage and its toxic effects.
Methods and materials: In 102 kidney transplant recipients, serum cyclosporine trough-peak levels, serum creatinine, blood urea, blood urea and nitrogen, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase were measured periodically from the beginning of May, 2011 until the end of July, 2012. The relationships among previous laboratory parameters were detected in relation to the prevalence of toxic cyclosporine effects.
Results: Consequently, the patients are with rena.. View More»
DOI:
10.4172/2161-0495.1000154