Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Ronald B. George
5850/5980 University Avenue, P.O. Box 9700, Halifax, NS, B3K 6R8
Canada
Research Article
Pregabalin Confers No Added Benefit to a Non-steroid Anti-inflammatory Drug
and Acetaminophen Regimen in Outpatient Breast Cancer Surgery: A
Randomized Controlled Trial
Author(s): Ronald B. George, Dolores M. McKeen, Colin Boyd J and Geoff A. PorterRonald B. George, Dolores M. McKeen, Colin Boyd J and Geoff A. Porter
Objectives: Multimodal analgesia may reduce both postoperative pain and the risk of adverse effects associated with opioid-use. Pregabalin has emerged as a potential perioperative analgesic with an improved pharmacokinetic profile. However, data regarding its analgesic efficacy and optimal dose following breast surgeries are conflicting. This study was designed to determine if perioperative treatment with pregabalin could reduce pain scores and oxycodone consumption following elective surgery for possible breast cancer.
Methods: Fifty-nine women undergoing elective breast cancer surgery (mastectomies and lumpectomies) were recruited for this study. Patients were randomized to pregabalin (150 mg) or placebo, both administered prior to surgery and 12 hours postoperatively. Pain and nausea intensity were measured using an 11-point numerical ratin.. View More»
DOI:
10.4172/2155-6148.1000383