Pancreatic Disorders & Therapy
Open Access
ISSN: 2165-7092
ISSN: 2165-7092
Raoudha Slim
Tunisia
Research Article
Drug-Induced Acute Pancreatitis Confirmed By Positive Re-challenge
Author(s): Neila Fathallah, Raoudha Slim, Sofien Larif, Houssem Hmouda, Jaballah Sakhri and Chaker Ben SalemNeila Fathallah, Raoudha Slim, Sofien Larif, Houssem Hmouda, Jaballah Sakhri and Chaker Ben Salem
Drug-induced pancreatitis is a rare but severe adverse drug reaction with an incidence of 0.1-2%. More recent reports have estimated an incidence of up to 5%. Over 500 medications have been associated with this disease. Recrudescence of pancreatotoxicity upon re-exposure to the suspicious drug is considered the more reliable evidence of drug-induced pancreatitis. A retrospective review of MEDLINE was conducted to assess clinical outcomes of positive drug re-challenge following possible drug-induced pancreatitis. A total number of 250 cases of drug-induced pancreatitis with positive re-challenge were identified, among which, 183 met inclusion criteria for analysis in our review. A broad spectrum of suspect drugs was identified. Analgesics and anti-inflammatory drugs were incriminated in 30% of all cases, antibacterials in 18.6%, and cardiovascular agents in 10.9% of cases, immunomodula.. View More»
DOI:
10.4172/2165-7092.S6-005