Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 7868 792050
ISSN: 2329-8790
+44 7868 792050
Ramesh Kumar
Kuwait
Short Communication
Isolated Defect of Intestinal Iron Absorption in Siblings of Iron Deficiency Anemia
Author(s): Sunny Joseph Varghese, Ramesh Kumar, Ahmad Allumai and Lamis M TawfikSunny Joseph Varghese, Ramesh Kumar, Ahmad Allumai and Lamis M Tawfik
Iron deficiency anemia (IDA) is the commonest type of anemia all over the world. It is easily treatable with oral iron therapy, but a minority of patients does remain unresponsive. This may be related to inappropriate compliance, manifest or occult blood loss, worm infestations, helicobacter infection, known malabsorption syndromes or paroxysmal nocturnal hemoglobinuria (PNH). We observed six such patients with non-responsive recurrent classical IDA who did not show any of the above conditions on specific investigations.
Iron tolerance test (as an index of oral iron absorption) was performed on these patients. All of them showed negligible or no iron absorption, suggesting a defect in intestinal oral iron absorption as the cause of non-responsive IDA. This contention was supported by a dramatic response to parenteral iron therapy in all of them. Since the tests for known malab.. View More»
DOI:
10.4172/2329-8790.1000220