Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
R J Holtby
Tanzania
Research Article
Comparison of the Macro-circulatory Effects of the New Generation
Plasma Expander EAF-HexaPEGylated Albumin (EAF-PEG-BSA) in a Rabbit
Hemorrhagic Shock Model: a Comparison with Conventional Crystalloid
and Colloid Solutions
Author(s): P L To, R A Gunther, J S Jahr, R J Holtby, B Driessen, S A Acharya, P C Chen and A T W Cheung
P L To, R A Gunther, J S Jahr, R J Holtby, B Driessen, S A Acharya, P C Chen and A T W Cheung
Introduction: HexaPEGylated albumin (PEG-BSA) is a new class of low viscosity Nitric Oxide (NO) producing active plasma expander.The macro-circulatory response to PEG-BSA of a 4 gm solution of PEG-BSA was studied in a rabbit hemorrhagic shock and resuscitation model and compared that of 0.9% sodium chloride and albumin 25%.
Methods: Five New Zealand white rabbits were anesthetized utilizing ketamine with diazepam and propofol. Endotracheal intubation was performed, animals were ventilated, and anesthesia maintained with isoflurane and diazepam. Following placement of vascular lines for measuring physiological variables, 45 minutes were allowed for equilibration prior to collecting baseline values laboratory and physiologic values. Animals were bled over 30 min to reach a Mean Arterial Pressure (MAP) of 30-41 mmHg .This pressure was maintaine.. View More»
DOI:
10.4172/2155-6148.1000343