Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Paula Sá
Portugal
Research Article
Spontaneous One-Lung Ventilation Increases the Lung Inflammatory
Response: An Experimental Pilot Study
Author(s): Humberto S Machado, Paula Sá, Catarina S Nunes, António Couceiro, Álvaro Moreira da Silva and Artur ÁguasHumberto S Machado, Paula Sá, Catarina S Nunes, António Couceiro, Álvaro Moreira da Silva and Artur Águas
Study objective: The purpose of this study was to investigate if spontaneous one-lung ventilation would induce any type of inflammatory lung response when compared to spontaneous two-lung ventilation and its intensity, by quantification of inflammatory cells in lung histology at the end of the procedure.
Design: In vivo prospective randomised animal study
Setting: University research laboratory
Subjects: New Zealand rabbits Interventions: Rabbits (n=20) were randomly assigned to 4 groups (n=5 each group). Groups 1 and 2 were submitted to one-lung ventilation, during 20 and 75 minutes respectively; groups 3 and 4 were submitted to two-lung ventilation during 20 and 75 minutes and considered controls. Ketamine/xylazine was administered for induction and maintenance of anesthesia. One-lung v.. View More»
DOI:
10.4172/2155-6148.1000428