Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Paul Kubler
Australia
Research Article
Gentamicin Monitoring Practices in Teaching Hospitals – Time to Undertake the Necessary Randomised Controlled Trial
Author(s): Jennifer Martin, Michael Barras, Nicholas Ah Yui, Carl Kirkpatrick, Paul Kubler and Ross NorrisJennifer Martin, Michael Barras, Nicholas Ah Yui, Carl Kirkpatrick, Paul Kubler and Ross Norris
Objective: To compare the clinical appropriateness of the prescribing and monitoring of gentamicin. Method: A retrospective study was undertaken at two tertiary teaching hospitals in Australia. 161 adult patients administered gentamicin and who had at least one serum concentration taken whilst an inpatient were eligible for analysis. The main outcome measures were adherence to local and national guidelines for dosing and monitoring of gentamicin, and percentage of the recommended measure of adequate gentamicin exposure (Area-Under the concentration-time Curve (AUC)) using a nomogram and a Bayesian calculation. Results: Results were similar in both hospitals. Initial dosing: Adherence to local and national dosing guidelines was poor - approximately 50% of initial doses using less than local and 88% less than national recommendations. Monitoring: Approximately 20% of all gentamicin conc.. View More»
DOI:
10.4172/2161-0495.1000146