Cell & Developmental Biology

Cell & Developmental Biology
Open Access

ISSN: 2168-9296

+12 184512974

Paul J. Higgins

Paul J. Higgins
Center for Cell Biology and Cancer Research,
Albany Medical College, 47 New Scotland Avenue, Albany, New York 12208

  • Review Article
    TGF-β1 Target Genes in Human Fibrotic Disease: From Molecular Mechanisms to Clinically-Relevant Therapies
    Author(s): Paul J. HigginsPaul J. Higgins

    Interstitial fibrosis is an end-stage pathophysiological feature of several clinically-important diseases involving the pulmonary, hepatorenal and cardiovascular systems and a common response to chronic injury, non-resolving inflammation or long-standing metabolic disease. Increased deposition of extracellular matrix (e.g., fibronectin, collagen), produced by persistently activated myofibroblasts, and attenuated matrix degradation results in disease progression. Disruption of normal tissue architecture eventually culminates in organ failure. Matrix turnover, in the context of both normal and abnormal wound repair, is regulated by several factors among which the most prominent ones are members of the transforming growth factor-β (TGF-β) superfamily. TGF-β1 stimulates fibronectin and collagen synthesis/accumulation at the wound site while impacting the extent and locale o.. Read More»
    DOI: 10.4172/2168-9296.1000110

    Abstract PDF

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