Anesthesia & Clinical Research
Open Access

Noboru Nagata

Publications

• Research Article
  Optimal Concentration of Sevoflurane to Prevent Cardiovascular Depression after Induction of General Anesthesia with Remifentanil and Propofol
  Author(s): Naotaka Kishimoto, Shinichi Koyama, Noboru Nagata and Junichiro Kotani Naotaka Kishimoto, Shinichi Koyama, Noboru Nagata and Junichiro Kotani
  
  Background: We examined the optimal concentration of sevoflurane to prevent cardiovascular depression after induction of general anesthesia with remifentanil and propofol. Methods: Seventy-five adult patients were randomized to one of three groups (n = 25). Midazolam (0.025 mg/kg) and remifentanil (0.5 ?g/kg/min) were administered to all patients, followed by propofol (1.0 mg/kg) and rocuronium (0.6 mg/kg) after 2 min. The lungs were ventilated manually with sevoflurane and oxygen via a tightly fitted face mask. The trachea was intubated when end-tidal sevoflurane concentration reached 1%, 1.5%, and 2% in each group, respectively. Three min after the start of administration, remifentanil was decreased to 0.25 ?g/kg/min. The effect-site concentration of remifentanil was 6.0 ng/ml for 4 min after it was started. Hemodynamic variables were reco.. View More»
  DOI: 10.4172/2155-6148.1000149

  Abstract PDF

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