Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Mworia JK
Kenya
Research Article
In Vivo Safety of Aqueous Extracts of Maytemus putterlickoides, Senna
spectabilis and Olinia usambarensis on Mice Models
Author(s): Mugweru FG, Nyamai DW, Arika WM, Mworia JK, Mworia JK, Ngugi MP, Njagi ENM and Ngeranwa JJNMugweru FG, Nyamai DW, Arika WM, Mworia JK, Mworia JK, Ngugi MP, Njagi ENM and Ngeranwa JJN
Plant products are used as the primary health care in developing countries due to their availability and affordability compared to conventional methods. It is estimated that more than 80% of the world’s population use herbal preparations in the management and treatment of diseases. Herbal products are now readily available in supermarkets and drug stores. The therapeutic value of these herbal products is believed to be due to the presence of bioactive elements present in the plant parts. Toxicity studies should, however be carried to ascertain the safety of the herbal preparation. In this study, safety studies were carried out through biochemical assays, histopathology and hematological tests. The plant extracts led to changes in body weight, hematological and histopathological changes like increase in lymphocyte number. High dose of orally administered Olinia usambarensis also .. View More»
DOI:
10.4172/2161-0495.1000305