Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Mohamed E. El-Boshy
Mansoura
Saudi Arabia
Research Article
Attenuation of CCl4 Induced Oxidative Stress, Immunosuppressive, Hepatorenal
Damage by Fucoidan in Rats
Author(s): Mohamed E. El-Boshy, Fatma Abdelhamidb, Engy Richab, Ahmad Ashshia, Mazen Gaitha and Naeem QustyaMohamed E. El-Boshy, Fatma Abdelhamidb, Engy Richab, Ahmad Ashshia, Mazen Gaitha and Naeem Qustya
The protective and therapeutic effects of fucoidan extract from Laminaria species against liver damage induced by CCl4 in rats was investigated by monitoring the serum level and hepatic m-RNA expression of TGFβ-1, liver and renal markers, as well as oxidative stress and antioxidant biomarker. Thirty six adult male albino rats were divided into 4 equal groups; one was used as a negative control while groups II, III, and IV administrated 0.1 mL/100 g body weight twice a week for 8 weeks with carbon tetrachloride (CCl4), fucoidan (400 mg/kgbw orally/day), and CCl4 plus fucoidan, respectively. Blood samples were collected at the end of experiment and sera were separated to evaluate serum levels and the hepatic m-RNA expression of transforming growth factor beta (TGFβ-1), tumor necrosis factor (TNF α), interferon gamma (IFN-γ.), interleukin (IL), Il-1β, IL-6 and .. View More»
DOI:
10.4172/2161-0495.1000348