Anesthesia & Clinical Research
Open Access

Michael J. Brown

Publications

• Research Article
  HMG-CoA Reductase Inhibitors Decrease Hyperglycemia on Animal Model of Systemic Inflammatory Response Syndrome (SIRS)
  Author(s): Pinar Aksoy, Michael J. Brown and Eduardo N. Chini Pinar Aksoy, Michael J. Brown and Eduardo N. Chini
  
  Systemic Inflammatory Response Syndrome (SIRS) is a pathophysiologic state associated with trauma and major surgery. Inflammatory cytokines plays an important role in the pathogenesis of SIRS. Cytokines induce the activation of the classic hypothalamic-pituitary stress response that leads to increase of secretion of the stress hormone ACTH and hyperglycemia. HMG-CoA reductase inhibitors, such as statins, have been shown to have anti-inflammatory properties. Recent studies in humans indicate that the perioperative use of statins may decrease morbidity and mortality. Here we tested the hypothesis that statins may decrease the cytokine-induced stress response and hyperglycemia in a murine model of SIRS. SIRS was induced with intraperitoneal injection of 0.1 mg lipopolysaccharide (LPS) per mouse. Mice were pretreated with 0.5 mg of simvastatin or lovastatin 18 hours before the administrat.. View More»
  DOI: 10.4172/2155-6148.1000165

  Abstract PDF

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