Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Mekbeb Afework
Ethiopia
Research Article
Evaluations of Biochemical, Hematological and Histopathological Parameters of Subchronic Administration of Ethanol Extract of Albizia Gummifera Seed in Albino Wistar Rat
Author(s): Mokennon Debebe, Mekbeb Afework, Eyasu Makonnen, AsfawDebella, Bekesho Geleta and Negero GemedaMokennon Debebe, Mekbeb Afework, Eyasu Makonnen, AsfawDebella, Bekesho Geleta and Negero Gemeda
Albizia gummifera are plants found in Ethiopia that have different medicinal values.The objective of the present study was to evaluate the toxicological effects of sub-chronic administered hydro-ethanolic (70%) seeds extract of Albizia gummiferain albino Wistar rats. The seeds of these plants were collected from different areas of Ethiopia. They were dried and crushed to powder and macerated with hydro-alcohol and placed in orbital shaker. The extract was then filtered through Whatman filter paper No.1 and the filtrate was evaporated to dryness by Rota vapor and further concentrated by water bath at 40ºC. The extract was packed in air tight brown glass bottles and kept in a refrigerator at 4ºC. The extract was then administered to rats at different doses to determine the LD 50 of the extract and at doses of 125 mg/kg/day and 250 mg/kg/day for the sub-chronic toxicity study. .. View More»
DOI:
10.4172/2161-0495.1000337