Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Mehmet Cantürk
Aşıkpaşa Hospital,
Turkey
Research Article
The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats
Author(s): Aykut Urfalıoglu, Mehmet Cantürk, Erkan Yavuz Akçaboy and Nermin GöğüşAykut Urfalıoglu, Mehmet Cantürk, Erkan Yavuz Akçaboy and Nermin Göğüş
Purpose: The presence or absence of protective or preventive role of dexmedetomidine and propofol against ischemia/reperfusion (I/R) injury at tissue level on liver I/R model was demonstrated.
Materials and methods: 24 rats were randomly divided into four groups. Following anesthesia laparotomy was done and hepatoduodenal ligament was explorated. Tissue samples were taken for both biochemical (MDA, SOD, GPx) and histological study.
Results: MDA level was hisghest in Group II and was significantly lower in Group III and Group IV. GPx level was lowest in Group II, the level of GPx was higher in Group III and Group IV with respect to Group II. SOD level was lowest in Group II and was highest in Group IV. SOD levels in Group II and Group III did not show statistical significance. In the histopathological study, in Grou.. View More»
DOI:
10.4172/2155-6148.1000358