Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Mayer Saidian
Beckman Laser Institute,
Irvine, California
Tanzania
Research Article
Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion
Author(s): Matthew Brenner, Sarah M Azer, Kyung-Jin Oh, Chang Hoon Ha, Jangwoen Lee, Sari B Mahon, Xiaohua Du, David Mukai, Tanya Burney, Mayer Saidian, Adriano Chan, Derek I Straker, Vikhyat S Bebarta and Gerry R BossMatthew Brenner, Sarah M Azer, Kyung-Jin Oh, Chang Hoon Ha, Jangwoen Lee, Sari B Mahon, Xiaohua Du, David Mukai, Tanya Burney, Mayer Saidian, Adriano Chan, Derek I Straker, Vikhyat S Bebarta and Gerry R Boss
Objective: Accidental or intentional cyanide ingestion is an-ever present danger. Rapidly acting, safe, inexpensive oral cyanide antidotes are needed that can neutralize large gastrointestinal cyanide reservoirs. Since humans cannot be exposed to cyanide experimentally, we studied oral cyanide poisoning in rabbits, testing oral sodium thiosulfate with and without gastric alkalization.
Setting: University research laboratory.
Subjects: New Zealand white rabbits.
Interventions: Seven animal groups studied; Groups 1-5 received high dose oral NaCN (50 mg, >LD100) and were treated immediately with oral (via nasogastric tube): 1) saline, 2) glycine, 3) sodium thiosulfate or 4) sodium thiosulfate and glycine, or 5) after 2 min with intramuscular injection of sodium nitrite and sodium thiosulf.. View More»
DOI:
10.4172/2161-0495.1000355