Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Masayuki Ohyama
1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025,
1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025
Japan
Research Article
Comparing Heat-treated Silica Particle with Silica Particles for the Ability to Induce Superoxide Release from Rat Alveolar Macrophages
Author(s): Masayuki Ohyama, Hideki Tachi, Chika Minejima and Takayuki KamedaMasayuki Ohyama, Hideki Tachi, Chika Minejima and Takayuki Kameda
Crystalline silica can devitrify with the formation of cristobalite and other crystalline silica species when exposed to prolonged high temperatures, which is of potential concern because crystalline silica is classified as carcinogenic. Silica particles activate macrophages to release oxidants, which contribute to inflammation and injury in the lower respiratory tract. Our aim was to compare silica particles with heat-treated silica particles for their ability to induce superoxide release from rat alveolar macrophages. We estimated the ability of four types of silica particle samples and heat-treated silica particles with different number average particle diameter to induce lucigenin-dependent chemiluminescence (CL) from macrophages based on the number of silica particles. A strong positive correlation was observed between particle diameter and the ability to induce CL in both the si.. View More»
DOI:
10.4172/2161-0495.1000199