Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Masayuki Ohyama
Osaka Prefectural Institute of Public Health,
Osaka 537-0025
Japan
Research Article
Histological Effect of Nitrous Acid with Secondary Products of Nitrogen
Dioxide and Nitric Oxide Exposure on Pulmonary Tissue in Mice
Author(s): Masayuki Ohyama, Kenji Oka, Shuichi Adachi and Norimichi TakenakaMasayuki Ohyama, Kenji Oka, Shuichi Adachi and Norimichi Takenaka
Numerous epidemiological studies of respiratory effects of nitrogen dioxide may have included exposures to nitrous acid, because conventional assays of nitrogen dioxide measure nitrous acid as nitrogen dioxide. A few epidemiological studies and human inhalation experiments of nitrous acid reported that nitrous acid is associated with decrements in lung function and possibly with respiratory symptoms. Moreover, our guinea pig exposure experiment of nitrous acid demonstrated that nitrous acid inducible the pulmonary emphysema-like disease and the architecture alterations of the alveolar duct centriacinar regions with the thickened interstitium. The purpose of this study was to assess the acute toxicity and the injury of exposure to nitrous acid with histopathological alterations in the respiratory tract in mice. We continuously exposed only filtered air and the filtered air with 8.4 ppm.. View More»
DOI:
10.4172/2161-0495.1000103