Cell & Developmental Biology
Open Access
ISSN: 2168-9296
+44 1478 350008
ISSN: 2168-9296
+44 1478 350008
Marilyn Silva
Tanzania
Research Article
Re-evaluation of Developmental and Reproductive Toxicity of Ortho- Phenylphenol (OPP) and Sodium Ortho-Phenylphenate (SOPP)
Author(s): Eric S.C. Kwok and Marilyn SilvaEric S.C. Kwok and Marilyn Silva
Background: Due to widespread usage, the general public including pregnant women is routinely exposed to the fungicides, Ortho-Phenylphenol (OPP) and Sodium Ortho‑Phenylphenate (SOPP), from many sources. Previous data reviews concluded no effects on development or reproduction in animal studies but upon re-analysis we realize that alternative interpretation may exist.
Methods: Developmental and reproductive effects were assessed from studies performed in rats, mice, and rabbits. We identified the most sensitive endpoint(s) for OPP or SOPP as they related to fetal developmental or reproductive toxicity. For quantifying the potential health risk associated with the exposure to OPP or SOPP, we used the lowest dose that caused no developmental or reproductive toxicity or benchmark dose analysis.
Results: Developmental effects in OPP-tre.. View More»
DOI:
10.4172/2168-9296.1000123