Pancreatic Disorders & Therapy
Open Access
ISSN: 2165-7092
+44 1478 350008
ISSN: 2165-7092
+44 1478 350008
Mari Mino-Kenudson
Massachusetts General Hospital,
55 Fruit Street, Warren 122, Boston, Massachusetts
Russia
Review Article
The Role of Molecular Analysis in Diagnosis and Risk Stratification of Intraductal Papillary Mucinous Neoplasm?A Precursor to Pancreatic Adenocarcinoma
Author(s): Vicente Morales-Oyarvide and Mari Mino-KenudsonVicente Morales-Oyarvide and Mari Mino-Kenudson
Pancreatic cancer is a leading cause of cancer death and most patients have advanced disease at the time of diagnosis, making early detection of paramount importance. Intraductal papillary mucinous neoplasm (IPMN) is a cystic precursor lesion to pancreatic cancer that is being diagnosed with increasing frequency often in asymptomatic patients. While some IPMNs may progress to invasive carcinoma and thus, require resection, others will remain insignificant and may be followed without surgical intravenation. Unfortunately, our understanding of the natural history of IPMN is limited, and we are not yet able to confidently segregate high-risk and malignant lesions from low-risk ones. Molecular profiling that allows us to gain insight into the biology of the disease may provide us with clues to improve preoperative decision making. In this review, we will discuss the most recent findings i.. View More»
DOI:
10.4172/2165-7092.S4-005