Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Manoj K Pandey
Pennsylvania State University College of Medicine,
Hershey, Pennsylvania,17033
Tanzania
Review Article
Targeting CXCL12/CXCR4 Axis in Multiple Myeloma
Author(s): Manoj K Pandey, Shipra Rastogi, Vijay P Kale, Tejas Gowda and Shantu G AminManoj K Pandey, Shipra Rastogi, Vijay P Kale, Tejas Gowda and Shantu G Amin
Multiple Myeloma (MM) is malignant haematological disease characterized by uncontrolled proliferation of monoclonal plasma cells (PC) in bone marrow (BM). The receptor, CXCR4 is widely expressed on hematopoietic cells including MM cells and respond to CXCL12 gradients for mobilization through blood stream and bone marrow. CXCL12 plays an important role in recruitment of MM cells to bone marrow microenvironment and formation of neoangiogenic niches supporting tumor growth, survival and metastasis. The integral role of this chemokine-receptor axis in development of MM makes it a desirable target for therapeutics. In this review, we outline the background on MM and role of specific chemokine CXCL12 in the disease with an attempt to highlight the targeted therapeutics for its signaling receptor CXCR4 in MM... View More»
DOI:
10.4172/2329-8790.1000159