Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Makoto Miyara
France
Research Article
Heavy/Light Chain Ratio as a Biomarker for Monitoring Patients with IgM Monoclonal Gammopathy and Anti-MAG Neuropathy
Author(s): Virginie Planche, Laurent Arnaud, Karine Viala, Marie Anne Hospital, Makoto Miyara, Jean Marc Leger, Jean Neil, Véronique Leblond and Lucile MussetVirginie Planche, Laurent Arnaud, Karine Viala, Marie Anne Hospital, Makoto Miyara, Jean Marc Leger, Jean Neil, Véronique Leblond and Lucile Musset
Background: Patients with neuropathy associated with anti-myelin-associated glycoprotein (MAG) antibodies are managed in part by the detection and whenever possible the measurement of IgM-component on serum protein electrophoresis (SPE). Hevylite™ is an immunoassay developed to quantify separately IgMκ and IgMλ and to calculate the IgMκ/IgMλ ratio (HLC ratio). We sought to determine whether HLC ratio can be used to assess diagnosis and to evaluate response to therapy in patients with anti-MAG neuropathy compared to the other currently available tests. Methods: In our tertiary care centre, we retrospectively studied a series of patients with anti-MAG neuropathy. Clinical data and serum samples were collected before treatment and between 6 months and one year maximum after treatment onset. Hevylite™ was performed in a second time after including all patie.. View More»
DOI:
10.4172/2329-8790.1000142