Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Maha R Habeeb
Egypt
Research Article
A Study of MicroRNA-24 Expression in Aflatoxin B1 Exposed Patients with Hepatocellular Carcinoma and Cirrhosis
Author(s): Afaf M Attia, Dina Elhammady, Maha R Habeeb, Neven F Abbas and Maysaa El Sayed ZakiAfaf M Attia, Dina Elhammady, Maha R Habeeb, Neven F Abbas and Maysaa El Sayed Zaki
Introduction: Over 80% of hepatocellular carcinoma (HCC) sufferers occur in developing countries as a result of exposure to hepatitis B or C viruses, through formation of cirrhosis or viral integration into host DNA on the part of HBV, or due to ingestion of aflatoxin B1 (AFB1) causing DNA damage in hepatic tissue with generation of mutations, particularly in p53 tumor suppressor gene. MicroRNAs are noncoding RNAs that have an effect on oncogene and tumor suppressor gene expression, hence partaking in carcinogenesis. A connection between HCC and dysregulated expression of microRNAs has been repeatedly demonstrated, suggesting that circulating microRNAs might potentially be used as biomarkers for pre-clinical HCC detection. We aimed in this study to assess the role of micro-ribonucleic acid-24 (microRNA-24) expression in patients with cirrhosis and HCC who have experie.. View More»
DOI:
10.4172/2161-0495.1000382