Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Luiz Eduardo Nunes Ferreira
School of Nurse,
Praça Teresa Cristina, 88, Guarulhos, São Paulo
Brazil
Review Article
Effects of Local Anesthetics on Cellular Necrosis, Apoptosis and Inflammatory Modulation: Short Review
Author(s): Luiz Eduardo Nunes Ferreira, Danish Hasan, Bruno Vilela Muniz, Jonny Burga-Sánchez, Maria Cristina Volpato and Francisco Carlos GroppoLuiz Eduardo Nunes Ferreira, Danish Hasan, Bruno Vilela Muniz, Jonny Burga-Sánchez, Maria Cristina Volpato and Francisco Carlos Groppo
Objectives: Local anesthetics (LAs) cause the loss of sensitivity to the nociceptive stimulus by the reversible blockade of the neural electrical impulse. These drugs are widely used for pain control in many clinical procedures and in other therapeutic applications. Besides the effects on voltage-gated sodium channels, LAs can modulate different cellular pathways. The review seeks to address the effects of local anesthetics on the cellular viability, apoptosis induction and inflammatory response.
Methods: Data was collected from MEDLINE®, Scopus® and Web of Science, the searches were performed between November 2017 and April 2018.
Results: LAs induce necrosis and apoptosis in a time and dose-dependent manner. Apoptosis occurs primarily by the intrinsic pathway through the loss of mitochondri.. View More»
DOI:
10.4172/2155-6148.1000826