Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Research Article
Wound Healing Effects of a Lipocalin-Derived Peptide
Author(s): Luana Wlian, Linda Christian Carrijo-Carvalho, Sonia Aparecida Andrade, Silvia Vanessa Lourenço, Consuelo Junqueira Rodrigues, Durvanei Augusto Maria and Ana Marisa Chudzinski TavassiLuana Wlian, Linda Christian Carrijo-Carvalho, Sonia Aparecida Andrade, Silvia Vanessa Lourenço, Consuelo Junqueira Rodrigues, Durvanei Augusto Maria and Ana Marisa Chudzinski Tavassi
The role of lipocalins in wound healing is currently unknown, although the involvement of these proteins in injury response has been reported. This study aimed to investigate the effects of a peptide comprising the sequence of a previously described lipocalin conserved motif (pM2b), in an experimental model of skin lesion. Circular full-thickness wounds in the skin of rat dorsum were treated with pM2b or saline as control, and allowed to heal, keeping the wound occluded and moist. During wound healing, the following parameters were evaluated in the regenerating tissue: wound closure, collagen content, glycosaminoglycans (GAGs) and metalloproteinase (MMP) activity. In addition, tissue sections were subjected to histological analysis. Treatment with pM2b promoted an overall improvement in wound healing and tissue repair, with distinctly marked signals in the early stages of wound healin.. View More»
DOI:
10.4172/2161-0495.1000187