Pancreatic Disorders & Therapy
Open Access

Lemstrova Radmila

Publications

• Case Report
  Pancreatic Ductal Adenocarcinoma Harboring Germline BRCA 2 Mutation, A Case Report and Review of The Literature
  Author(s): Lemstrova Radmila, Melichar Bohuslav, Mohelnikova-Duchonova BeatriceLemstrova Radmila, Melichar Bohuslav, Mohelnikova-Duchonova Beatrice
  
  Introduction: Despite recent advances in the diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC) the prognosis of this tumor remains dismal. It is estimated that 5-10% of all PDAC patients harbor a germline BRCA-1 or BRCA-2 mutation. There is some evidence that BRCA-mutated PDAC cases respond to chemotherapy regimens based on platinum derivate and cross linking agents. Case report: Here we present a case of metastatic PDAC in a 41-year-old BRCA2 germline mutation carrier. The patient had a favorable response to systemic treatment, including a partial response even to the third line cisplatin monotherapy administered with palliative intent. Discussion: PDAC associated with BRCA mutation represents a special disease entity. Platinum derivates and cross linking agents should be considered even in the advanced palliative setting in these patients. .. View More»
  DOI: 10.4172/2165-7092.1000182

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