Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Koji Goto
Department of Anesthesiology and Intensive Care, Oita University Hospital, 1-1 Idaigaoka, Hasama, Yuhu, Oita 879-5593,
Japan
Research Article
Continuous Renal Replacement Therapy Improves Septic Shock in Patients Unresponsive to Early Goal-Directed Therapy
Author(s): Koji Goto, Seigo Hidaka, Takakuni Abe, Ryo Shitomi, Norihisa Yasuda, Shunsuke Yamamoto, Satoshi Hagiwara and Takayuki NoguchiKoji Goto, Seigo Hidaka, Takakuni Abe, Ryo Shitomi, Norihisa Yasuda, Shunsuke Yamamoto, Satoshi Hagiwara and Takayuki Noguchi
Background: Early goal-directed therapy (EGDT) has been shown to improve patient outcomes. Treatment of patients unresponsive to the protocol, however, is difficult and the result is occasionally fatal. Recently, continuous renal replacement therapy (CRRT) has been used to treat acute kidney injury (AKI) to improve survival. We examined the effectiveness of CRRT in treating septic shock patients with concurrent AKI who are not amenable to EGDT.
Methods: We studied 17 patients who underwent emergency surgery for intra-abdominal infection; these patients experienced AKI complications and did not respond to EGDT within 6 hrs after intensive care unit (ICU) admission. We treated patients with continuous venovenous hemodiafiltration (CVVHDF; dialysis = 900 ml/hr, filtration = 900 ml/hr, total hemopurification = 1800 ml/hr). We measured mean arter.. View More»
DOI:
10.4172/2155-6148.1000161