Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Kirsten Vistisen
Denmark
Case Report
Cardiotoxicity in Asymptomatic Patients Receiving Adjuvant 5-fluorouracil
Author(s): Karin Nielsen, Anne Polk, Dorte L Nielsen, Kirsten Vistisen and Merete Vaage-NilsenKarin Nielsen, Anne Polk, Dorte L Nielsen, Kirsten Vistisen and Merete Vaage-Nilsen
Evolving evidence of cardiotoxicity in cancer patients treated with 5-fluorouracil (5-FU) has been reported. We report two different clinical manifestations of asymptomatic 5-FU-associated cardiotoxicity in patients operated for colorectal cancer and treated with adjuvant chemotherapy of 5-FU (bolus-injection and continuous infusion for 46 hours), folinic acid and oxaliplatin (FOLFOX). For a research study evaluating cardiac events during 5-FU treatment, Holter monitoring, electrocardiogram (ECG) and echocardiography were done and cardiac markers monitored before and during the first treatment course. Case report 1 presents a 75-year old woman with a medical history of paroxysmal atrial fibrillation, hypertension and hyperlipidemia. Holter monitoring revealed increasing paroxysms of atrial fibrillation, increased ventricular ectopic activity and episodes of sinoatrial arrest during in.. View More»
DOI:
10.4172/2161-0495.1000211