Anesthesia & Clinical Research
Open Access

Ken Johnson

Publications

• Research Article
  Prediction Variability of Combined Pharmacokinetic Pharmacodynamic Models: A Simulation Study of Propofol in Combination with Remifentanil and Fentanyl
  Author(s): Carl Tams and Ken JohnsonCarl Tams and Ken Johnson
  
  Introduction: The aims of this study were to estimate model prediction variability for drug concentrations and effects during a simulated propofol-remifentanil-fentanyl anesthetic and identify the change in propofol infusion rates or fentanyl bolus doses necessary to detect changes in the duration of selected drug effects. We hypothesized that drug effect variability is large when drug concentrations are within the dynamic range of concentration effect curves (i.e. during emergence from anesthesia), but when drug concentrations are above or below the dynamic range variability is small. Methods: 1000 parameter sets were randomly generated from published pharmacokinetic model parameters and their metrics of variability and published pharmacodynamic remifentanil-propofol interaction model parameters and their metrics of variability for loss of re.. View More»
  DOI: 10.4172/2155-6148.1000393

  Abstract PDF

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