Anesthesia & Clinical Research
Open Access

Keisuke Shihara

Publications

• Research Article
  Effects of the Antioxidant-Enriched Concentrated Liquid Diet ANOM on Oxidative Stress and Multiple Organ Injury in Patients with Septic Shock: A Pilot Study
  Author(s): Shigekiyo Matsumoto, Hironori Koga, Junya Kusaka, Satoshi Hagiwara, Keisuke Shihara, Shinya Kai, Chihiro Shingu, Taichi Nishida and Takayuki Noguchi Shigekiyo Matsumoto, Hironori Koga, Junya Kusaka, Satoshi Hagiwara, Keisuke Shihara, Shinya Kai, Chihiro Shingu, Taichi Nishida and Takayuki Noguchi
  
  Purpose: In patients with septic shock, excessive production of reactive oxygen species (ROS) by activated neutrophils injures the vascular endothelium. The body responds by recruiting systemic antioxidants, among which vitamin C most rapidly responds. Excessive and prolonged ROS production quickly depletes vitamin C, which is not synthesized by the human body. To improve the prognosis of patients with septic shock, we evaluated the ability of an antioxidant-enriched liquid diet to alleviate oxidative stress and multiple organ failure. Methods: We evaluated 15 patients with septic shock complicated by multiple organ failure who underwent treatment with ANOM® (antioxidant-enriched concentrated liquid diet, Otsuka Pharmaceutical Co, Tokushima, Japan). Vitamin C concentration was determined by measuring serum levels of vitamin C radicals (V.. View More»
  DOI: 10.4172/2155-6148.1000155

  Abstract PDF

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