Cell & Developmental Biology

Cell & Developmental Biology
Open Access

ISSN: 2168-9296

+44 20 3868 9735

Kao LP

Kao LP
Mayo Clinic,
Scottsdale, 13400 East Shea Boulevard Scottsdale, Arizona

  • Review Article
    Mitochondrial Dysfunction and Mitophagy in Neurodegenerative Diseases
    Author(s): Kao LP and Wolvetang EJKao LP and Wolvetang EJ

    Mitochondria are critical in providing energy for neuronal development. They provide the majority of intracellular energy and perform important metabolic functions such as the Krebs cycle. Mitochondria contain their own mitochondrial DNA in a circular form, similar to bacterial genomes. Mitochondrial genomes encode several essential genes of the eukaryotic respiratory machinery, but most respiratory machinery components and factors controlling mitochondrial biogenesis are encoded in the nucleus. Mitochondria and the nucleus cooperate and communicate via retrograde signals, such as energy supply and redox signaling. This poorly understood communication is essential for balancing intracellular energy production and demand. Mitochondrial mutations could lead to dysfunctions in ATP production, calcium homeostasis, reactive oxygen species generation, and apoptotic signaling. Thus, mitochon.. Read More»
    DOI: 10.4172/2168-9296.1000184

    Abstract PDF

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