Journal of Hematology & Thromboembolic Diseases
Open Access

Justin Kline

Publications

• Review Article
  Novel Immunotherapy to Eliminate Minimal Residual Disease in AML Patients
  Author(s): Hongtao Liu and Justin KlineHongtao Liu and Justin Kline
  
  Even with the most sophisticated chemotherapy regimens, the majority of patients with acute myeloid leukemia will eventually experience a relapse and die from their disease. New treatments are needed to prevent relapse of disease in these patients. Immunotherapy using the host immune system to combat leukemia represents an exciting and potentially efficacious addition to standard chemotherapy for AML. Immune-base treatments may be particularly effective when administered at a time when patients are in clinical remission with normal blood counts; nevertheless, these patients often have minimal residual disease which eventually results in disease relapse. Successful vaccinationbased immunotherapy targeting leukemia-specific antigens will likely require the administration of powerful immune adjutants and removal of negative immune regulatory pathways in order to achieve maximal efficacy... View More»
  DOI: 10.4172/2329-8790.1000112

  Abstract PDF

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