Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
ISSN: 2157-7013
Jinbo He
IR Iran
Research Article
Effect of L-arginine on Function of Mitochondria in Ischemia – Reperfusion Myocardial Cell in Rabbits
Author(s): Chen D, Huang L, Jinbo He, Song D, Yingchun Ma, Lina Lin and Wang WChen D, Huang L, Jinbo He, Song D, Yingchun Ma, Lina Lin and Wang W
Objective: To investigate the effect of L-arginine (L-Arg) on the function of myocardial mitochondria during myocardia ischemia - reperfusion (IR). Methods: Dividing randomly the 30 rabbits into three groups (n=10): control group (C), myocardia ischemiareperfusion group (IR) and L-Arginine pretreatment group (L-Arg+IR). The relevant parameters, including myocardial mitochondria respiratory function, Ca2+ concentration ([Ca2+]), malondialdehyde (MDA) concentration, superoxide dismutase (SOD) activity, myocardial adenosine triphosphate (ATP), Adenosine diphosphate (ADP), adenosine monophosphate (AMP) content, the total amount of AMP (TAN, TAN=ATP+ADP+AMP) and energy charge (EC, EC=1/2ADP+ATP/TAN) were determined, respectively. Results: The mitochondria respiratory control rate (RCR), III state respiration rate (V3), and SOD in group L-Arg +IR were significantly higher than those in grou.. View More»
DOI:
10.4172/2157-7013.1000166