Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Jianjun Liu
8 Longyuan Road, Nanshan District, Shenzhen 518055
China
Research Article
Dynamic Change of Serum Proteomics of Occupational Medicamentosalike
Dermatitis Induced by Trichloroethylene
Author(s): Wei Liu, Wen-xu Hong, Yawen Zhang, Xiaohu Ren, Peimao Li, Zhimin Zhang, Haiyan Huang, Xinfeng Huang, Yanfang Zhang and Jianjun LiuWei Liu, Wen-xu Hong, Yawen Zhang, Xiaohu Ren, Peimao Li, Zhimin Zhang, Haiyan Huang, Xinfeng Huang, Yanfang Zhang and Jianjun Liu
Objective: Extensive researches about biomarkers of Occupational medicamentosa-like dermatitis induced by Trichloroethylene (OMLDT) have been carried out in recent years. But dynamic change of protein biomarkers in serum has rarely been reported. The aim of our study was to explore the dynamic changing law of serum proteins/ polypeptides in different periods of OMLDT, identify potential biomarkers and provide the scientific fundamentals for monitoring the progression of the disease and screening high-risk population.
Study design: We developed an approach in the combination of magnetic beads based weak cation exchange chromatography (MB-WCX), matrix assisted laser desorption ionization time of flight mass spectrometry (MALDITOF- MS) and ClinProTools software. Based on the alternations in the polypeptides fingerprint of serum (PFS), we built .. View More»
DOI:
10.4172/2161-0495.1000275