Sorbonne University, UPMC University,
Paris 06, and Assistance Publique Hôpitaux de Paris,Department of Hepatogastroenterology, Hôpital Pitié Salpêtrière, Paris
Squamous-Cell Gallbladder Carcinoma: How to Treat?
Author(s): Lea Verlicchi, Hélène Blons, Laurent Hannoun and Jean-Baptiste BachetLea Verlicchi, Hélène Blons, Laurent Hannoun and Jean-Baptiste Bachet
Squamous-cell gallbladder carcinoma is a very rare cancer with very few therapeutic data available in the literature. We describe a case of this rare disease with a good response under Gemcitabine and Cisplatin after several previous lines of chemotherapy, in an 80-year-old man. In our case, the disease was resistant to FOLFOX, FOLFIRI and Paclitaxel but an impressive partial response was shown after 9 cycles of Gemcitabine and Cisplatin in fourth-line of chemotherapy. Unfortunately, a progression occurred after 12 cycles (7 months). With the intent of finding a new therapeutic option a molecular analysis was performed using Next-Generation Sequencing and two mutations of ERBB2 and PTEN were found. A standard regimen of chemotherapy for squamous-cell gallbladder cancer does not exist and, because of the rarity of this type of cancer, therapeutic trials will probably never be conducted.. Read More»