Journal of Cell Science & Therapy

Journal of Cell Science & Therapy
Open Access

ISSN: 2157-7013

Jean-Baptiste Bachet

Jean-Baptiste Bachet
Sorbonne University, UPMC University,
Paris 06, and Assistance Publique Hôpitaux de Paris,Department of Hepatogastroenterology, Hôpital Pitié Salpêtrière, Paris

  • Case Report
    Squamous-Cell Gallbladder Carcinoma: How to Treat?
    Author(s): Lea Verlicchi, Hélène Blons, Laurent Hannoun and Jean-Baptiste BachetLea Verlicchi, Hélène Blons, Laurent Hannoun and Jean-Baptiste Bachet

    Squamous-cell gallbladder carcinoma is a very rare cancer with very few therapeutic data available in the literature. We describe a case of this rare disease with a good response under Gemcitabine and Cisplatin after several previous lines of chemotherapy, in an 80-year-old man. In our case, the disease was resistant to FOLFOX, FOLFIRI and Paclitaxel but an impressive partial response was shown after 9 cycles of Gemcitabine and Cisplatin in fourth-line of chemotherapy. Unfortunately, a progression occurred after 12 cycles (7 months). With the intent of finding a new therapeutic option a molecular analysis was performed using Next-Generation Sequencing and two mutations of ERBB2 and PTEN were found. A standard regimen of chemotherapy for squamous-cell gallbladder cancer does not exist and, because of the rarity of this type of cancer, therapeutic trials will probably never be conducted.. View More»
    DOI: 10.4172/2157-7013.1000212

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