Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
ISSN: 2329-8790
Jan Jacques Michiels
Goodheart Institute & Foundation in Nature Medicine & Health,
Rotterdam
Netherlands
Review Article
Polycythemia Vera era 1939-1998 from Berkeley to Rotterdam and Change of PVSG into ECP Criteria of Myeloproliferative Disorders ET, PV and PMGM: Proceedings of the First Rotterdam MPD Workshop 1998 and beyond
Author(s): Jan Jacques Michiels
Jan Jacques Michiels
The PVSG defined in 1975 the myeloproliferative disorders (MPD) essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) or agnogenic myeloid metaplasia (AMM) are three distinct disease entities with regard to clinical manifestations, natural history and outcome in terms of life expectancy. The European Clinical and Pathological (ECP) criteria demonstrated that fibroblast proliferation in PVSG defined PMF and post-ET and post-PV myelofibrosis is polyclonal indicating that myelofibrosis (MF) is secondary in all variants of myeloproliferative syndromes. By including bone marrow histopathology the ECP defined between 1998 and 2000 the prefibrotic MPDs ET, PV and primary megakaryocytic granulocytic myeloproliferation (PMGM) as three distinct myeloproliferative disease (MPD) entities. Clinical, hematological and morphological characteristics, in particular me.. View More»
DOI:
10.4172/2329-8790.1000280