Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Isabelle Kao
Tanzania
Commentary
Hemodynamic Response to Dynamic Changes in Upper Airway Impedance–A Volunteer Study
Author(s): Ottokar Stundner, Thomas Danninger, Isabelle Kao, Peter Gerner and Stavros G MemtsoudisOttokar Stundner, Thomas Danninger, Isabelle Kao, Peter Gerner and Stavros G Memtsoudis
Introduction: Intermittent airway obstruction may occurring both intubated and non-intubated critically ill patients due to endotracheal tube obstruction or kinking in the former and loss of oropharyngeal tone particularly during sedation in the latter patient group. Spontaneous breathing efforts against high airway resistance invoke shifts in intrathoracic pressure, which could potentially negatively affect cardiac performance. Previous studies utilized the Mueller Maneuver as a model for pathophysiologic changes during these episodes. However, this model only accounts for the state of maximum inspiration. To study progressive airway obstruction of various degrees, we devised an experimental setup allowing for a dynamic simulation and identification of associated short-term effects of breathing against discretely increasing airway resistance. Material and methods: 14 healthy voluntee.. View More»
DOI:
10.4172/2155-6148.1000317