Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Innayat- Ur- Rehman
Pakistan
Research Article
Chemical Composition and Biological Screening of Essential Oils of Zanthoxylum armatum DC Leaves
Author(s): Barkatullah, Muhammad Ibrar, Naveed Muhammad, Innayat- Ur- Rehman, Mujeeb-Ur-Rehman and Ajmal KhanBarkatullah, Muhammad Ibrar, Naveed Muhammad, Innayat- Ur- Rehman, Mujeeb-Ur-Rehman and Ajmal Khan
Essential oil (ZVO) from Zanthoxylum armatum was extracted through hydro-distillation and tested for various biological activities. A total of 34 chemical constitutes were identified through GC-MS, the major constituents of ZVO were beta- Linalool (53.05%), Bergamot mint oil (12.73%), alpha-Limonene diepoxide (11.39%), alpha- pinene (4.08%), beta- Myrcene (3.69%) and D-Limonene (3.10%). ZVO showed significant antispasmodic effect and relaxed the isolated rabbit jejunum in spontaneous as well as in potassium chloride induced contraction. The maximum effect was observed against M. leutus followed by B. subtilis with percent zone of inhibition 28.45 and 20.45, respectively. A concentration dependent effect was also observed against available species of fungi. The maximum effect was observed against M. canis, C. albicans and C. glabrata with percent activity 84.87, 83 and 79, respectively.. View More»
DOI:
10.4172/2161-0495.1000172