Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
ISSN: 2157-7013
In-Kyu Lee
Republic of Korea
Research Article
Imatinib Induces Growth Inhibition via Down Regulation of SKP2 in A431Human Skin Squamous Cell Carcinoma Cells
Author(s): Sung-Hyun Kim, Hyo Jin Jeong, Yonghun Seong, Song Park, Jain Jeong, Dong Joon Kim, In-Kyu Lee, Zae Young Ryoo and Myoung Ok KimSung-Hyun Kim, Hyo Jin Jeong, Yonghun Seong, Song Park, Jain Jeong, Dong Joon Kim, In-Kyu Lee, Zae Young Ryoo and Myoung Ok Kim
S-phase-kinase-associated protein 2 (SKP2) plays a crucial role in the tumorigenesis of various human cancers. Imatinib, an inhibitor of BCR-ABL tyrosine kinase, c-kit, and platelet derived growth factor receptors, has been approved for the treatment and investigation of chronic myeloid leukemia, gastrointestinal stromal tumors, and various other solid tumors. However, its efficacy in the treatment of skin squamous cell carcinoma (SSCC) has not yet been investigated. The aim of this study was to investigate whether imatinib has an antitumor effect in human SSCC cells and evaluate its functional relationship with SKP2. To research the effect of imatinib on the growth of A431 SSCC cells, we conducted a proliferation assay and flow cytometry. A western blot assay was performed to verify the function of imatinib in A431 cells and evaluate the underlying molecular mechanism. Imatinib signi.. View More»
DOI:
10.4172/2157-7013.1000277