Pancreatic Disorders & Therapy

Pancreatic Disorders & Therapy
Open Access

ISSN: 2165-7092


Hildegard M Schuller

Hildegard M Schuller
College of Veterinary Medicine,
2407 River Drive, Knoxville, TN 37996

  • Review Article
    The Neuro-Psychological Axis of Pancreatic Cancer as a Novel Target for Intervention
    Author(s): Hildegard M SchullerHildegard M Schuller

    This review summarizes experimental and clinical data in support of the hypothesis that the known risk factors for Pancreatic Ductal Adenocarcinoma (PDAC), smoking, psychological stress, alcohol consumption, diabetes and pancreatitis-, create hyperactivity of the neurotransmitters norepinephrine and epinephrine in the pancreas. Smoking, psychological stress and alcohol sensitize the nicotinic acetylcholine receptors (nAChRs) that regulate the synthesis and release of PDAC stimulating stress neurotransmitters norepinephrine and epinephrine by nerves of the symapthicus, the adrenal gland and by pancreatic cancer cells and their epithelial precursor cells while simultaneously desensitizing the nAChRs that govern the synthesis and release of the PDAC inhibiting neurotransmitter g-aminobutyric acid (GABA). Experimental data generated in vitro and in animal models emphasize a key role of Gs.. Read More»
    DOI: 10.4172/2165-7092.1000124

    Abstract PDF

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