Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
ISSN: 1948-5964
Hermann Bussmann
Botswana
Short Communication
Validation of A Point-of-Care Lactate Device For Screening At-Risk Adults Receiving Combination Antiretroviral Therapy In Botswana
Author(s): Sikhulile Moyo, Hermann Bussmann, Phibeon Mangwendeza, Priti Dusara, Tendani Gaolathe, Madisa Mine, Rosemary Musonda, Erik van Widenfelt, Vladimir Novitsky, Joseph Makhema, Richard G. Marlink, Max Essex and C. William WesterSikhulile Moyo, Hermann Bussmann, Phibeon Mangwendeza, Priti Dusara, Tendani Gaolathe, Madisa Mine, Rosemary Musonda, Erik van Widenfelt, Vladimir Novitsky, Joseph Makhema, Richard G. Marlink, Max Essex and C. William Wester
Background: Nucleoside reverse-transcriptase inhibitors (NRTIs) are a major component of combination antiretroviral therapy (cART) worldwide but they have been associated with mitochondrial toxicities, with one of the most significant being lactic acidosis. In southern Africa, being female and overweight (BMI > 25) as well as receiving d4T and/or ddI-based cART are risk factors for the development of this potentially life-threatening complication. It is challenging in many resource-limited settings to obtain reliable serum lactate measurements while screening for the presence of lactic acidosis. Point-of-care devices, however, are now available that provide simple, accurate measurements of serum lactate levels at relatively low cost. The objective of this study was to assess the agreement of the portable (Accutrend™ handheld) lactate analyzer to the conventional laboratory sy.. Read More»
DOI:
10.4172/jaa.1000034