Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Hela Ghorbel
Bioprocess Laboratory, Division of Regional Excellence AUF (PER-LBP), Centre of Biotechnology of Sfax (CBS),
BP: 11773038 Sfax
Tunisia
Research Article
Benefic Interactive Effects between Garlic Consumption and Serum Iron Excess
Author(s): Hela Ghorbel, Ines FKI, Choumous Kalel, Jamoussi Kamel and Sami SayadiHela Ghorbel, Ines FKI, Choumous Kalel, Jamoussi Kamel and Sami Sayadi
Hemochromatosis is the most common form of iron overload disease. In case of pathological serum iron increase, kidney is the first organ directly affected. Moreover, anemia is the major symptom of most cases of kidney failure and oxidative stress is thought to be a significant factor in the pathogenesis of iron-overload disease. Garlic, was recently demonstrated as inhibitor of intestinal iron absorption. The purpose of this study was to show that crude garlic consumption in case of serum iron increase could prevents biochemical and histological kidney perturbations and ameliorates hematological parameters. For this, four groups of young rats were treated for forty five days: control group C, iron overload group I, garlic overload group G and both garlic and iron overload group IG. In iron treated rats (group I) all haematological parameters showed a decrease. Moreover, kidneys showed.. View More»
DOI:
10.4172/2161-0495.1000224